Endianness is about byte address order. Little endian means the lower significant bytes get the lower addresses. Big endian means the other way around. So it's about the bytes (8-bit chunks) not nibbles (4-bit chunks). Most computers we use (there are a few exceptions) address bytes at the individual address level.
Taking the -12
example:
Little endian, in memory, would be:
000000: F4
000001: FF
Big endian, in memory, would be:
000000: FF
000001: F4
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