You can call window.location.reload(true) to reload the current page. It will ignore any cached items and retrieve new copies of the page, css, images, JavaScript, etc from the server. This doesn't clear the whole cache, but has the effect of clearing the cache for the page you are on.
However, your best strategy is to version the path or filename as mentioned in various other answers. In addition, see Revving Filenames: don’t use querystring for reasons not to use ?v=n as your versioning scheme.
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