r - ID conversion from Drosophila Gene Symbols to Human Gene Symbols

Question

I am looking for an R solution (or a general logic solution) to convert Drosophila melanogaster gene ids into Homo sapiens gene ids. Using R/BiomaRt is problematic, due to the ever-changing nature of the BiomaRt dataset, and its dependence on an internet connection and server status.

The gene ids are in the FlyBase format, but I also have human-friendly gene symbols, e.g.

FBgn0259938 cwo
FBgn0036285 toe
FBgn0264490 Eip93F
FBgn0034903 sona

Any idea? Thanks!

question from:https://stackoverflow.com/questions/65848648/id-conversion-from-drosophila-gene-symbols-to-human-gene-symbols

Answer 1

I think you can use the FlyBase orthologs table, which is periodically updated and also has DIOPT scores for each ortholog: ftp://ftp.flybase.net/releases/current/precomputed_files/orthologs/dmel_human_orthologs_disease_fb_2020_06.tsv.gz