I agree with what others say that the subject is very vague. Never the less I will attempt to express my thoughts on the matter and show you how I'm doing it on my blog.
I use both WebPage and Blog item types in the same document to mark up different things.
Web page
I use WebPage item type on the body tag (but you can also use any other parent of the breadcrumb). By doing so I can mark up my bread crumbs.
<body itemscope itemtype="http://schema.org/WebPage">
<ul itemprop="breadcrumb">
<li>
<a href="foo">foo</a>
</li>
<li>
<a href="foo/bar">bar</a>
</li>
<li>
<a href="foo/bar/baz">baz</a>
</li>
</ul>
...
</body>
Blog postes
When I loop the blog posts I use the Blog item type on the wrapper that contains all of the blog articles. I mark every article with the property blogPosts and uses of course BlogPosting as item type.
<section itemscope itemtype="http://schema.org/Blog">
<article itemprop="blogPosts" itemscope itemtype="http://schema.org/BlogPosting">
...
</article>
<article itemprop="blogPosts" itemscope itemtype="http://schema.org/BlogPosting">
...
</article>
...
</section>
Article page
See edit below for an update to this opinion
On the articles landing page I don't use the Blog item type. But I do mark the post as a BlogPosting item.
<article itemscope itemtype="http://schema.org/BlogPosting">
...
</article>
The only reason I can see that you would wanna mark something with a Blog item type is because of the blogPosts properties and the fact to say that it is a blog. I think you fulfill saying that it's a blog by marking the article as a BlogPosting.
I also don't think it's correct using the property in this context since this is used in a plural form. To me that reflect a different area of use.
Edit
I'm not sure if the schema has extended or if I missed it the first time around, but the Blog item has a property called blogPost now, that is the singular form blogPosts. So then I would say that it makes more sense to mark up the main element as the Blog item and use the blogPost property for the article and mark it up as a BlogPosting item
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